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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.7 kg (7.7%) relative to placebo. Of note, however, only one participant in the placebo group continued receiving treatment. Thus, a very low dose (1.7%) of ostarine significantly increase LBM over 3 months, while a higher dose (4.8%) did not have much of an effect. An 8-week-long clinical trial conducted with 17 adults using ostarine and metformin resulted in a total increase in LBM of 6.4 kg (18.3%), with both ostarine and metformin having similar effects on fat, body composition, and cardiovascular performance as an 8-week-long study with 27 obese subjects using oleic acid and simvastatin (4). Taken together, the results of these two studies suggests that ostarine may be a safe and efficient anabolic agent for use in individuals suffering from sarcopenia due to aging. Ostarine can enhance bone mineral density and decreases body fat without the negative effects of diuretics, glucocorticoids, and certain steroids (5). Ostarine also has been shown to accelerate bone turnover (6, 7). Additionally, ostarine can promote greater protein synthesis (8), which is the primary target for protein-maintaining diets. Because testosterone and its sulfated derivatives, dihydrotestosterone, and estradiol accumulate in the body, their elimination is necessary to maintain normal bone mineral density (9). In our clinical study with our participants (n = 28), ostarine was superior to metformin in restoring LBM following an exercise regimen (12). Interestingly, we found a greater change in body fat compared with the placebo group, possibly attributable to ostarine's anabolic activity. Given the increased risk of anorexia associated with decreased levels of testosterone, our findings would suggest ostarine's anabolic effect was dose-dependently superior to metformin with respect to body fat. The observed effect is supported by several large-scale clinical trials in which ostarine caused a weight loss of approximately 24% in women with low levels of testosterone and decreased bone mineral density (10, 11) without a change in body fat. Another possibility is that ostarine may enhance metabolism by increasing skeletal muscle production and utilization (12), or by increasing the efficiency of glycogen reabsorption by the liver through the reduction of the rate at which glycogen is converted into glucose in the liver (13). However Similar articles: