To minimise severe flare-up, slow withdrawal is recommended by decreasing how often the topical steroid is applied and choosing another topical steroid that is less potentto trigger greater adverse reactions and to minimise the chance of infection.There have been small randomised controlled trials that have demonstrated efficacy of testosterone in conjunction with buccal or buccal transdermal patches on mild to moderate acne, as compared to placebo in subjects with moderate to severe acne.The benefits of buccal patch on acne are generally more relevant in subjects who have at least some other acne-related condition than those with a pure mild acne phenotype, as this class of subjects often have more symptoms than would be typical of the subjects with milder acne. As the severity of acne varies across a number of dermatological conditions, the use of buccal patch therapy is preferred in those with moderately severe acne.There are no current data on buccal patch therapy for the treatment of Acne vulgaris in combination with other acne treatments, effects of steroid cream overuse. However, in patients with persistent facial skin lesions, treatment of the lesions with topical steroids alone may be effective and would have minimal adverse effects.One randomized controlled trial has shown the results of buccal patch treatment to be comparable to the results of using topical corticosteroids.topical steroids Topical corticosteroids have a much longer treatment duration than injectables, whereas topical steroids only have a half-life of several hours. The efficacy of topical steroids is associated with an increased adverse event profile, topical steroid cream over the counter.topical steroids have a much longer treatment duration than injectables, whereas topical steroids only have a half-life of several hours, topical steroid withdrawal 5 years. The efficacy of topical steroids is associated with an increased adverse event profile, effects of steroid cream overuse. There have be a number of studies that have evaluated the effects of topical steroids on the facial appearance of patients with acne. One of the most prominent findings from these studies is the effectiveness of topical steroids and the need for frequent application.topical steroids should not be prescribed to acne patients as their treatment may be harmful. The benefit of topical steroids for acne patients is likely to be associated with a greater tendency for acne vulgaris to spread and may not be as effective as the use of topical corticosteroids. topical steroids should not be prescribed to acne patients as their treatment may be harmful. There is no controlled data available on the use of topical steroids for acne, other than a small number of small controlled trials, effects of steroid cream overuse0.